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Because of this interaction with the CYP450 enzymes, the prescription drugs or cannabinoids may become more concentrated in the system, which could reduce the efficacy of the drug or result in increased negative side effects from the medication

[DOI] [PubMed] [Google Scholar] Borio G.The Tobacco Timeline

Bovio, F., Melchioretto, P., Forcella, M., Fusi, P

Harm Reduction: What the Science Says About Herbal Smoke A 2022 comprehensive review published in ACS Omega confirmed that herbal cigarettes produce tar, carbon monoxide, polycyclic aromatic hydrocarbons (PAHs), and aromatic amines during combustion, with some herbal smoke showing higher mutagenic potential than tobacco smoke at equivalent tar concentrations

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