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Duration varies by individual, but most people use each pouch for 20-60 minutes

Nicotine C-oxidation to nicotine 5(1)iminium ion is followed by a second oxidation that generates cotinine, which is further metabolized to trans 3-hydroxycotinine (3-HCOT), a reaction that is catalyzed almost exclusively by CYP2A6 (see Fig

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The natural oils within the leaf maintain a steady ember, allowing for a long-lasting session without constant relighting

Regular cigarette smokers have long been known to be at risk of the incurable chronic obstructive pulmonary disease (COPD)