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Unfortunately, these studies have a limited duration, so long-term efficacy in weight control, end points of obstructive sleep apnea, and cardiovascular risk remain to be seen

Furthermore, PC1/3 colocalization with glucagon was elevated in liraglutide-treated WT mice compared with that in liraglutide-treated KO mice (Figure 1, D and E

IDrugs Investig Drugs J (2009) 12:50313
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1,2 This restriction is based on animal studies where semaglutide and tirzepatide caused thyroid C-cell tumours in rats
