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The attenuated yet significant effect size in the matched cohort aligns with expectations from causal mediation frameworks, where partial confounding adjustment reduces but does not eliminate true effects [20]

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In a study on the biological effects of marine worms from cigarettes, healthy marine worms were compared to marine worms that were exposed to cigarettes for a prolonged amount of time

p53 upregulates the damage-regulated autophagy modulator 1 ( DRAM1 ), which codes for a lysosomal protein that is required for the induction of autophagy [80]