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Semaglutide 2.4 mg (Wegovy ) and tirzepatide (Zepbound ), approved for the treatment of obesity in 2021 and 2024, respectively, produced corresponding mean weight loss of 17% and 23% in clinical trials of subjects with obesity, but without T2D (16, 17)
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The Inflation Reduction Act of 2022 6.5.1

These effects typically subside as your body adapts

The second exendin-4-derived GLP-1 receptor agonist to be used clinically was lixisenatide