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Leave-one-study-out analyses (Supplementary Table 1) revealed some variability in p-values ( P = 3.1 10 7 7.4 10 9 for rs2714700 and P = 5.6 10 9 3.9 10 6 for rs1862416), likely due to fluctuating statistical power given the significant correlation between N (sample size) and p-value across iterations: r = 0.65, P = 8.6 10 5

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Whilst some brands can contain up to 28mg of nicotine per cigarette, it is typical for between only 1.1mg and 1.8mg of nicotine per cigarette to enter the bloodstream, as a large quantity is lost in the burning process