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All authors contributed to the development of the study methodology

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Once a chemical mostly associated with cigarettes, and their health consequenceswhich are actually a result of toxic chemicals from tobacco rather than nicotinethe stimulant has become, in its smokeless form, an unlikely pre-workout pick-me-up

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124 Eight studies investigated the association of heaviness of smoking with later depression, of which seven (88%) found evidence to support this association, 11,82,95,102,125,127,128 while one (13%) found no evidence of an association