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This reinforces a potential crosstalk between both transcriptional regulators
microRNA-34a overexpression will increase p53 acetylation and transcription, which leads to the diminishment of sirtuin 1 (SIRT1) in the NAFLD liver
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
Of note, p53 R270H but not p53 R172H also acted in a dominant-negative manner in promoting tumorigenesis when the other allele was WT for p53
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