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doi: 10.1001/jamainternmed.2014.187

Nicotine (absorbed into the blood through the vapour produced by the ENDS) is likely to only enter the brain between 5 and 20 seconds after each inhalation 11 , and modelling this effect within a conventional fMRI design would be difficult, since the timing of the nicotine hit after each trial is somewhat uncertain

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Methadone is a substrate of CYP2B6, which is induced by PAH exposure in smokers

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I will review it at the end of each month and see if it needs to be adjusted