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[DOI] [PubMed] [Google Scholar] 81.Lawrence BM

Arterial blood gas levels typically indicate a mixed respiratory alkalosis and metabolic acidosis

Interestingly, it should be noted that the data from the present study revealed substantial mitochondrial remodeling and elevated oxidative stress, which can amplify the stimulation of group III/IV afferents and increased the susceptibility to muscle fatigue thus providing an alternative mechanism by which exercise intolerance develops in these patients (16, 17)

The pulmonary hydrocarbon receptor (AHR) is activated by benzo[a]pyrene (BaP), a component of cigarette smoke that binds to AHR and induces expression of P4501A1, or CYP1A1