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It suggested that this may be due to a decrease in the expression level of PRKN, a key mediator of mitophagy, leading to insufficient mitochondrial clearance and the accumulation of ROS (Ito et al., 2022)

If health warnings, a ban on tobacco advertising, and tons of education about the risks of smoking dont do the trick, what can we possibly do to save the hundreds of thousands of people dying from smoking-related diseases in the United States every year

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