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Additionally, some IBS patientsparticularly those with IBS-C (constipation-predominant)may experience worsening of slow transit and constipation when starting GLP-1 medications, as these drugs naturally slow gastric emptying

The risk of bias for each included study was assessed using the Cochrane Risk of Bias (ROB2) tool, rating each domain as low [1], moderate [2], or high [3] risk, see Supplement 9

Medicare prescription drug plans had not previously covered medications designed to help patients lose weight.

Many plans require prior authorization, which is when your provider submits information about why you need the medication, and the insurer will decide if they will cover it

This approachsupported by real-world dataallows your GLP-1 receptors to fully adapt while maintaining weight loss momentum

Maintain your current retatrutide dose
