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Those who used to smoke slightly less than a pack a day, had a 24% increased risk of erectile problems, and for those who averaged more than 20 cigarettes a day, the risk of ED increased by 39%

State of California Department of Justice - Office of the Attorney General

Furthermore, SLUDGE syndrome can also occur, which is a cholinergic condition, expressing as increased bodily secretions such as saliva, lacrimal fluid, and features such as diarrhoea, gastro-intestinal upset, urinary incontinence, and vomiting

[PMC free article] [PubMed] [Google Scholar] Grucza RA, Bierut LJ