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doi:10.1021/acs.est.6b01741 Hess CA, Olmedo P, Navas-Acien A, Goessler W, Cohen JE, Rule AM

The assumptions and parameters we used are outlined in the table for the base case scenario

anandamide AG: Arachidonylglycerol AMPK: Adenosine monophosphate-activated protein kinase AOM: Azoxymethane BC: Breast cancer BID: Twice a day BRCA: Breast cancer susceptibility protein CAF: Cancer-associated fibroblasts CB: Cannabinoids receptor CBD: Cannabidiol CBN: Cannabinol CDAI: Crohn's Disease Activity Index Cdc: Cyclin-dependent kinase CNS: Central nervous system COX: Cyclooxygenase CRC: Colorectal cancer CRPC: Castration-resistant prostate cancer DAI: Disease activity index DNA: Deoxyribonucleic acid DR: Death receptor ECS: Endocannabinoid system EMV: Exosome and macrovesicle FAAH: Fatty acid amide hydrolase FAP: Familial adenomatous polyposis GABA: Gamma-aminobutyric acid GPR: G-protein-coupled receptor HNPCC: Hereditary nonpolyposis colorectal cancer IBD: Inflammatory Bowel Disease IL: Interleukin LHRH: Luteinizing hormone-releasing hormone LPI: Lysophosphatidylinositol MAGL: Monoacylglycerol Lipase MMJ: Medical marijuana MMTV: Mouse mammary tumor virus MV: Macrovesicle NE: Neuroendocrine PC: Prostate cancer PG: Prostaglandin PPAR: Peroxisome proliferator-activated receptor TGF: Transforming growth factor THC: Tetrahydrocannabinol TID: Three times a day TRAIL: TNF-Related Apoptosis-Inducing Ligand TRP: Transient receptor potential USP: United States Pharmacopoeia VEGF: Vascular endothelial growth factor WHO: World health organization References Ahmed L

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