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That would represent the biggest change for e-cigarettes

Effectiveness of a large, nation-wide smoking abstinence campaign in the Netherlands: a longitudinal study

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47 Rather than fighting the FTC, the industry lobbied Congress to pass the 1965 Cigarette Labelling and Advertising Act that required a weak first-generation text warning label, Caution: Cigarette smoking may be hazardous to your health [emphasis added], on package side and preempted the FTC or any other government agency from requiring a stronger warning on packages or in advertising (ref

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Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats