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This resembled the rate of increase in CR levels with each population doubling (Figure 2, B and C), indicating that creatinine ribosylation, and not creatinine availability, was the rate-limiting step for the conversion of creatinine to CR

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[15] Cruz-Jimenez, L., Barrientos-Gutirrez, I., Zavala-Arciniega, L., Arillo-Santilln, E., Gallegos-Carrillo, K., Rodrguez-Bolaos, R., Gravely, S., & Thrasher, J