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The data implied that while smoke exposure induced microbiota disruption and emphysema, structural lung damage alone did not maintain the altered microbiota, indicating that microbial shifts might not directly contribute to emphysema progression [86]

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The more complete answer Most of the studies of smoking and testosterone compare levels of the hormone between groups of men who smoke with levels in a group or groups who either never smoked and/or are ex-smokers

Stroke 32 , 28829 (2001)