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Most people with treated hypothyroidism can safely use GLP-1 or GLP-1/GIP medications under medical supervision, provided they do not have certain rare thyroid cancer risks

For one thing, your natural GLP-1 stimulates insulin secretion in response to meals, helping to lower blood glucose levels

Furthermore, central GLP-1 is a physiological modulator of stress-induced colonic motility in the rat, since centrally but not peripherally administered GLP-1 increase fecal output after immobilization stress, an effect reverted by exendin (939), a competitive antagonist at GLP-1R [179]

Results Overall structure The tirzepatideGIPRG s , tirzepatideGLP-1RG s , peptide 20GIPRG s , peptide 20GLP-1RG s and peptide 20GCGRG s structures were determined by the single-particle cryo-EM approach with overall resolutions of 3.4 , 3.4 , 3.1 , 3.0 , and 3.5 , respectively (Fig

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Ziyad Al-Aly, the studys lead author and a chief researcher at the VA St