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The few studies available are cross-sectional studies focused on analyzing the impact of aspects such as smoking duration on COPD14,15 and a casecontrol study with a small sample size focused on analyzing the relationship between age at onset or smoking duration and COPD.17 Therefore, the relationship and influence of several aspects related to tobacco consumption are not clear

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The relationship between premature skin aging and smoking was first described in 1856

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The IQOS is composed of three main components: Given the novel technology of the IQOS, some industry stakeholders see this product as a potential precedent for the premarket review process that ENDS products will eventually undergo