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Description
Available data are contradictory when assessing the risk of perianal disease, since it was included in the definition of the fistulizing CD pattern in the initial Vienna phenotypic classification of CD[28], but not in the Montreal adaptation[29]

The toxins from smoking can put additional stress on the liver and other organs responsible for detoxification

Nicotine and Cigarette Smoke Modulate Nrf2-BDNF-Dopaminergic Signal and Neurobehavioral Disorders in Adult Rat Cerebral cortex#

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The exact amount of nicotine varies by brand
