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A case study reported vaping induced seizures with a tonic-clonic seizure beginning while the patient was driving, and after hospital admission and stabilization, re-initiation of a tonic-clonic seizure began minutes after vaping in the emergency department [94]

Nicotine is the main addictive chemical found in tobacco smoke, coming from the plant itself

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The continuation of this process and the release of additional inflammatory cytokines from the cell led to cell death 51

The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]