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Notably, various exendin-4-based GLP-1RAs (Exenatide: 39 aa and Lixisenatide: 44 aa), and GLP-1-based GLP-1RAs (Dulaglutide: 31 aa, Liraglutide: 31 aa, Semaglutide: 31 aa, Tirzepatide: 39 aa, and Albiglutide: 60 aa) have been developed and approved by the FDA between 2005 and 2022 for the management of T2DM ( Interestingly, until now, primarily long-chain peptides with 3339 amino acids have been developed as GLP-1RAs, which also carry a cost burden

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It can also lead to better relaxation and sleep and improved quality of life

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