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Reference: Kleinman RA and Barnett BS JAMA Network 2024

While the initial purchase price of IQOS is higher than other tobacco products, it is important to note that PMI has employed promotional price strategies in the past to lower prices

Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a dominant-positive mechanism

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As is often the case, out-of-the-box thinking was the key to radical innovation