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Avraham T., Yan A., Zampell J

doi: 10.1093/eurheartj/ehz486 6 American Diabetes A

A combination treatment of semaglutide, trevogrumad and garetosmab causes fat loss and muscle growth in primate trials
To obtain a GLP1-RG s complex with good homogeneity and stability, we used the NanoBiT tethering strategy, in which the C-terminus of rat G1 was linked to HiBiT subunit with a 15-amino acid polypeptide (GSSGGGGSGGGGSSG) linker and the C-terminus of GLP-1R was directly attached to LgBiT subunit followed by a TEV protease cleavage site and a double MBP tag (Supplementary Fig

10.1007/s00429-014-0714-z Summary Keywords GLP-1, obesity, diabetes, CNS, insulin Citation Heppner KM and Perez-Tilve D (2015) GLP-1 based therapeutics: simultaneously combating T2DM and obesity
