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Patients with type 2 diabetes have an impaired insulin response to GLP-1 that is believed to be secondary to reduced post-prandial GLP-1 secretion [60]

We chose to characterize CT-859 in this study because it has similar signaling properties at mouse receptors as CT-868 has at human receptors, a once daily dual-biased GLP-1R/GIPR agonist currently in phase 2 clinical trials

Exendin 4 shows great structural (53% conformity in amnio acid sequence) and functional similarity to human GLP-1

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Structural insight into antibody-mediated antagonism of the glucagon-like peptide-1 receptor

Aronne founded and directs the Comprehensive Weight Control Center, a state-of-the-art multidisciplinary obesity research and treatment facility, and has written three books including his most recent, Change Your Biology Diet: The Proven Program for Lifelong Weight Loss