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Taking protein 1530 minutes before a meal to reduce postprandial glucose is well-supported in the clinical literature

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In one phase 2 trial of people with obesity, some of whom also had type 2 diabetes, participants lost 20.5% of their fat mass while increasin g their lean muscle mass by 3.6% over 48 weeks of treatment

4 Semaglutide (Ozempic, Wegovy): 86.4% of study participants lost at least 5% body weight

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In contrast, liraglutide still reduced food intake in mice with GLP-1R knockout limited to autonomic neurons including vagal afferent neurons (phox2b-Cre