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Mechanism-focused studies may include receptor-pathway assays, biomarker panels, gene-expression analysis, protein-expression studies, cell-viability controls, migration assays, metabolic marker analysis, or stability testing

The objective of this review is to establish a link between METH and the microbiota from the gut and oral cavity, based on the available evidence, to gain insight into the potential bidirectional roles of the gut and oral microbiota in METH addiction and METH-related multi-organ toxicity, and to develop future therapeutic strategies

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