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They were drawn from a health research network that used electronic health records from over 120 health care organizations at various levels

Enck P, Rathmann W, Spiekermann M, et al

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Cells were lysed in KRBH + 0.1% Triton X-100 and sonicated, while islets were lysed in acidic ethanol (75% ethanol, 15 mM HCl)