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In addition, clinicians should be aware of the complex nature of KUD, both because kratom use often occurs in the context of polysubstance use, and also because the nature of kratom itself (with multiple alkaloids each having multiple actions) mimics the effects of multiple substances, with features of OUD but also of other SUDs, most notably StUD (or the technically undiagnosable caffeine use disorder)

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doi: 10.1016/j.cppeds.2022.101202