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Description
Pre-clinical studies done on C57BL/6J mice using total body irradiation (9 Gy) found that radiation reduced -diversity of gut microbiota, while urolithin A (UroA), a gut microbial metabolite, helps in alleviating radiation-induced apoptosis in intestinal cells by suppressing P53 signaling pathway (Zhang et al., 2021c

Sorafenib is the only first-line therapeutic in clinical practice for advanced HCC treatment by inducing apoptosis and impeding angiogenesis (Dixon et al., 2014

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376 To block Notch signaling, -secretase inhibitors such as RO4929097 have been developed and have shown preclinical efficacy in reducing CSC populations and increasing sensitivity to standard therapies

Nutr Neurosci 25(11):2288301 elik H, Kucukler S, omakl S, Caglayan C, zdemir S, Yardm A, Karaman M, Kandemir FM (2020) Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats

In all studies, data represent biological replicates (n) and are depicted as mean values SD or mean values SEM as indicated in the figure legends