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Pre-clinical studies done on C57BL/6J mice using total body irradiation (9 Gy) found that radiation reduced -diversity of gut microbiota, while urolithin A (UroA), a gut microbial metabolite, helps in alleviating radiation-induced apoptosis in intestinal cells by suppressing P53 signaling pathway (Zhang et al., 2021c

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Sorafenib is the only first-line therapeutic in clinical practice for advanced HCC treatment by inducing apoptosis and impeding angiogenesis (Dixon et al., 2014

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376 To block Notch signaling, -secretase inhibitors such as RO4929097 have been developed and have shown preclinical efficacy in reducing CSC populations and increasing sensitivity to standard therapies

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Nutr Neurosci 25(11):2288301 elik H, Kucukler S, omakl S, Caglayan C, zdemir S, Yardm A, Karaman M, Kandemir FM (2020) Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats

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In all studies, data represent biological replicates (n) and are depicted as mean values SD or mean values SEM as indicated in the figure legends

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