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American Spirits, for example, use an orange pack for its lightest cig, while Malboro employs silver and orange

These long-term effects can be serious or even deadly

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While early adolescence represents a window of vulnerability, experimentation and regular use become more prevalent in mid-late adolescence

Possible mechanisms The stable nicotine dependence levels over a year in e-cigarette and combined cigarette users compared to those using conventional cigarettes may be attributed to the oxidizing free-based nicotine produced by e-cigarette devices [24]

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