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Description
The National Institute of Standards and Technology (NIST) has issued a reference material with certified amounts of nicotine and two carcinogens to help ensure accurate testing of commercial tobacco fillerthe blended tobacco found in cigarettes

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-Dihydroionone, another carotenoid degradation product, is commonly employed for its floral, woody, and fruity fragrance [25]

Testing for Abuse Liability of Drugs in Humans (PDF)
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These are life-threatening conditions
