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At a customers request the tobacco was either cut to smoke or chew, or rasped to create snuff, as is sometimes indicated on jars with the inscription RAPPE (from the French tabac rapp : finely grated tobacco for a strong, moist snuff)

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The administration of nicotine into the LC, the A2 (norepinephrine-containing neurons) and C2 (epinephrine-containing neurons) regions of the nucleus of the tractus solitarius, and the A1 region of the ventrolateral medulla stimulates the release of ACTH (Matta et al., 1993b)