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With a dose-dependent response, the serum level of cotinine, the primary metabolite of nicotine catabolism, was correlated with increased naive (CD45RA + ) and decreased memory (CD45RO + ) CD3 + CD4 + T cells
As a result, tolerance builds far faster, leading to nicotine consumption that ensures the substance stays in the body far longer
The FDA said the rejection of Juul's applications was based on inadequate toxicological data, a claim the company disputes
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