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With that conversion in mind we can safely estimate a 30mL bottle of nicotine e-liquid would be about 15 packs of traditional cigarettes

PMID: 25745382

A science-led framework would distinguish between combustible cigarettes and non-combustible alternatives, maintain high product standards, prevent youth access, and preserve adult access to products that may help reduce smoking-related harm

Kwon, H.-J

Substance Abuse and Mental Health Services Administration (2013) Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings

Cotinine's presence in the body serves as an indicator of recent nicotine exposure rather than actively producing nicotine's effects