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The aetiology of coronary heart disease is multifactorial, among which there are non preventable and preventable risk factors

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The failure to articulate a clear methodology for APPH, grounded in market and behavioral realities, is part of a wider, long-standing problem: FDA has never set out, in detail or even in principle, how it believes the benefit-cost assessment implicit in APPH should be made, and this guidance does not address this deficit at all

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