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In brief, the major mechanisms of smoking-induced CV disease (many of which are overlapping) are 1) oxidative injury, 2) endothelial damage and dysfunction, 3) enhanced thrombosis, 4) chronic inflammation, 5) hemodynamic stress, 6) adverse effects on blood lipids, 7) insulin resistance and diabetes, 8) reduced oxygen delivery by red blood cells, and 9) arrhythmogenesis

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The rate of COPD in nonsmokers has declined, but it continues to rise in smokers

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Its considered the most aggressive of the group and the most likely to turn into cancer

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