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Nicotine is classified as a pharmaceutical agent in Japan under the Pharmaceuticals and Medical Devices Act (Act on Securing Quality, Efficacy and Safety of Pharmaceuticals, Medical Devices, Regenerative and Cellular Therapy Products, Gene Therapy Products, and Cosmetics)

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Among those receiving treatment for drug dependence worldwide, opioid dependence is the most common cause (50-85% of patients)

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For tobacco and marijuana smoke, respectively, 4350 and 2575 different compounds are detected, of which, 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause negative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms

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