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Longitudinal studies have shown that adolescents who begin with e-cigarettes are significantly more likely to transition to combustible tobacco products, a progression that reopens pathways to the very cancer risks that decades of tobacco control sought to close

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Likewise, EC use increased oral microbiome dysbiosis, with higher -diversity and altered -diversity compared to non-users

Secondly, the inherent noise of the imaging system further exacerbates the fluctuation: in the low-light band (400500 nm), the dark current of the CCD significantly reduces the signal-to-noise ratio (SNR) to approximately 15 dB