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In addition to regulating inflammatory factors, DNMT1 can also be activated by inflammatory factors, such as IL - 6 , transforming growth factor beta 1 [117] and IL - 1 [118]

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Most UVB radiation can reach the epidermal stratum corneum layer and the upper dermis, leading to dermal changes through epidermis-to-dermis signaling, while long-wave UVA penetrates more deeply into the dermis, reaching the subcutaneous layer of the skin [6]
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