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[4] [3] A major reason hypothyroid patients need closer monitoring on GLP-1 therapy is that weight loss can alter thyroid hormone requirements

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In fact, all evidence-based professional guidelines since 2016 have advocated that obesity medications be available in individualized care plans

Accordingly, SASP directly mediates pancreatic -cell dysfunction, adipose tissue dysfunction and insulin resistance in peripheral tissues, which promote the onset of T2D and vice versa [189]