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Effective use of ustekinumab in a patient with concomitant psoriasis, vitiligo, and alopecia areata

PPARs as master regulators of carnitine homeostasis Genes regulated by peroxisome proliferator-activated receptor (PPAR) are involved in many biological processes such as fatty acid catabolism, ketogenesis and gluconeogenesis, and also play a key role in the regulation of carnitine homeostasis [189]

Hoogeveen RC, Ballantyne CM

Based on the described scenario, current medical strategies basically aim to offer antioxidant supplementation, immune system modulation, and melanocyte precursor mobilization

Redox proteomic analysis of brain samples demonstrated that increased OS affects the final degradative process of autophagy, which relies on the activity of the vacuolar [H + ]-ATPase (V 0 -ATPase) and cathepsin D, both oxidized in AD individuals and in DS persons at risk of developing AD (233, 298, 342, 357)