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Nicotiana tabacum was also domesticated in the Andes from several wild species, probably after rustica and cultivated in the warmer regions of North American from meso-America to the Caribbean

The treatment of smoking by US physicians during ambulatory visits: 1994 2003

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Potentially toxic furans, which are byproducts of the thermal decomposition of sugars, and pyridines, which are produced following the thermal decomposition of nicotine, were detected in the emissions from HTPs and CCs, but are not commonly seen in emissions from ECs [12]