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149 The Challenge Group has produced several reports reviewing the progress made in reducing smoking in pregnancy in England, including the most recent: Getting back on track: Delivering a smokefree start for every child in 2021

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The candidate genes that play a key role in nicotine addiction include those associated with the dopaminergic neurotransmitter system (e.g., DRD2, DRD3, DRD4), cellular transport system (e.g., SLC1A2, SLC6A4), serotonergic neurotransmitter system (e.g., HTR2A), nicotinic neurotransmitter system (e.g., CHRNA4, CHRNA5, CHRNA3, CHRNA7, CHRNB4), opioidergic activity (e.g., OPRM1), and nicotine metabolism (e.g., CYP2A6) (55)