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Figure 6 2.6 PCD and the immune microenvironment of COPD As demonstrated by the various types of PCD described above, the remodeling of the immune microenvironment in COPD is not driven by a single mode of cell death, but rather the result of the superimposed effects of multiple PCDs across different cell types and disease stages: at the level of cell lineage, structural cells (airway/alveolar epithelium, vascular endothelium, smooth muscle, fibroblasts) primarily undergo apoptosis, necroptosis, ferroptosis, and cuproptosis, which together determine barrier integrity, the degree of airway remodeling, and the extent of alveolar destruction