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Description
Are GLP-1 Medications Worth the Cost
A comprehensive meta-analysis of 11 trials involving 85,373 participants demonstrated that GLP-1 RAs reduced composite kidney outcomes by 18% (HR 0.82, 95% CI 0.730.93), kidney failure by 16% (HR 0.84, 0.720.99), MACEs by 13% (HR 0.87, 0.810.93), and all-cause death by 12% (HR 0.88, 0.830.93) in participants with type 2 diabetes [94,95]
What Evidence Helps the Most
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Proposed mechanisms encompass modulation of nuclear factor-kappa B (NF-B), tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), C-reactive protein (CRP), reactive oxygen species pathways, and downstream metabolic networks that regulate insulin signal transduction (1, 2)
