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78 One source of such knowledge is the publicly available Adverse Outcome Pathway (AOP) Wiki created by the European Commissions DG Joint Research Centre (JRC), the US Environmental Protection Agency (EPA), and the Organization for Economic Co-operation and Development (OECD), which is a theoretical framework that describes a sequence of events and mechanisms by which chemicals can cause adverse human health effects

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The legislation also prohibits the sale of tobacco substitutes, such as e-cigarettes, to those under 21

[PubMed: 16829336] Cutler DM, Gruber J, Hartman RS, Landrum MB, Newhouse JP, Rosenthal MB