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In 2011, over one half million cocaine users ended up in the hospital emergency room due to misuse of cocaine

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In Japan, even though the legal age of adulthood under civil law was lowered to 18 in 2022, the age limits for drinking alcohol and smoking remain at 20

Notably, among those aged 11 years and less, ever (25.0%) and current (17.6%) e-cigarette use, and dual use (10.3%) was higher than in the other ages

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This study suggests the possibility of harm reduction if e-cigarette use were completely substituted for tobacco smoking, although the study was not designed to answer this question and selection into the cohort for nonusers was unclear