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In terms of previously published reports, our findings for the 2003/04 to 2007/08 interval, for example, are consistent with the CDC estimates indicating that the proportion of current adult smokers did not change noticeably from 2004 to 2008 37,38

In step 3, following the GRADE approach 192,193 , we quantified risk of bias across six domains, namely, representativeness of the study population, exposure, outcome, reverse causation, control for confounding and selection bias

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Stop use and ask a doctor if: skin redness caused by the patch does not go away after four days, or if your skin swells, or you get a rash