glp-1 receptor in brain biology: structure, signaling, and distribution Study identifies gut-brain-immune network influencing
Description
Its currently the only Health Canada-approved dual receptor agonist for treating obesity or overweight
Ramai D, Mozell D, Facciorusso A, et al
Challa and colleagues showed that increased concentrations of GLP-1 or its analogue liraglutide stimulated 3T3-L1 pre-adipocyte differentiation in vitro , and injection of 100 g/kg liraglutide twice daily for 17 days in mice fed a high fat diet for 6 weeks increased adipogenesis as compared with vehicle-treated mice [75]
When patients increase from 0.25 mg to 0.5 mg weekly (or equivalent oral doses), the GI tract is exposed to stronger receptor activation
van Duinkerken E, Bernardes G, van Bloemendaal L, et al
doi: 10.1016/S0140-6736(24)00351-9
